Adaptogen Research Hist Diamine 60 Vcaps

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$52.00

Feature

  • Supports Healthy Degradation of Food-Derived Histamine
  • Enhances the Presence of Diamine Oxidase in the Digestive Tract
  • Compare to Xymogen HistDAO

Product Detail

Product Description

HistDAOTM is a patented enzyme formula containing diamine oxidase (DAO)-the main enzyme responsible for the degradation of ingested histamine. This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract. DAO is not absorbed and does not have systemic activity. HistDAO does not manage or address antibody-related or IgE-related food allergies. Histamine/DAO balance Endogenous and exogenous histamine must be broken down in order to maintain homeostasis and histamine balance. The enzyme diamine oxidase (DAO) degrades histamine by converting it from 2-(4-imidazolyl)-ethylamine to the inactive metabolite imidazole acetaldehyde.[2] The active ingredient in HistDAO is porcine-derived diamine oxidase, and research suggests that DAO derived from porcine kidney appears to have identical action to DAO derived from porcine intestine.[3] In humans and other mammals, DAO is found in high concentrations in the gastrointestinal mucosa. Animal studies suggest that circulating DAO may be a marker for mucosal integrity and maturity.[4] Certain drugs may affect histamine balance in the body by promoting histamine release or inhibiting DAO. Ultimately, diminished serum DAO levels appear to be associated with changes in histamine degradation and serum histamine levels.[10] Although the mechanism of histamine degradation is uniform throughout the body, HistDAO only addresses excess exogenous histamine found in the folds, villi, and microvilli of the small intestine. HistDAO is not absorbed and therefore does not have systemic activity. A two-capsule dose of HistDAO contains 20 mg of vitamin C and 20,000 HDU (histamine degrading units) from diamine oxidase. HistDAO is NOT EFFECTIVE for symptoms of immune-related food allergies, such as peanuts, shellfish, etc. Serving Size: 2 Capsules Amount Per Serving %Daily Value Vitamin C (as ascorbic acid) 20 mg 33% Diamine Oxidase (from porcine kidney protein concentrate) 20,000 HDU **